Best Chargers vs. Chiefs NFL player props at BetMGM: Can Travis Kelce find the end zone in Brazil?

The 2025 NFL season got underway Thursday night in an eventful opener in Philadelphia that saw a player ejected before the first play from scrimmage as well as a lightning delay, and we've got a Friday night game on the docket as the Los Angeles Chargers take on the Kansas City Chiefs in an AFC West clash in Sao Paulo, Brazil. With this being the lone game of the night as we are treated to a rare Friday NFL game, that means there's no shortage of NFL player props available at BetMGM Sportsbook. Both teams are coming off postseason appearances and feature plenty of big names on offense, as the Chiefs are coming off their fifth Super Bowl appearance in six years while the Chargers made the playoffs in Jim Harbaugh's first year in charge.  

What NFL player props should you target for Friday's Chiefs vs. Chargers matchup when placing NFL bets at BetMGM? Here are some of the best NFL player props for Friday.

Best NFL player props for Chargers vs. Chiefs

Both sides feature plenty of stars and big names on offense, which means there's no shortage of NFL betting options at BetMGM. Here are a few player props to keep an eye on in Friday's matchup.

Omarion Hampton anytime TD scorer (+120, BetMGM)

We all know Harbaugh loves to run the football. He's leaned on the run game at both the college and pro levels, winning a national championship at Michigan with that formula and having a ton of success in San Francisco as well, leading the 49ers to three NFC Championship appearances and a Super Bowl. Harbaugh's team ran it OK last year, finishing 17th in rushing yards with just 4.1 per carry.

Omarion Hampton is tasked with giving the Chargers' run game a boost after the team took him in the first round. The Chargers also signed former Steelers lead back Najee Harris in free agency, but he doesn't offer the same game-breaking ability Hampton does. Plus, Harris missed most of the offseason with an eye injury, meaning Hampton may be in line for the bulk of the work in Week 1. 

The Chiefs have a stout rushing defense, allowing the eighth-fewest rushing yards last year, but Hampton has big-play ability and can score from anywhere on the field. The Chargers should be able to move the ball between the run game and Justin Herbert using his arm to attack downfield, and be it near the red zone or further down the field, I like Hampton to get loose and make a house call in his first NFL game. 

Travis Kelce anytime TD scorer (+160, BetMGM)

Travis Kelce didn't secure his fourth Super Bowl ring after the Chiefs fell to the Eagles, but he did give out a ring of his own this offseason with the news that he is engaged to superstar artist Taylor Swift. The Swifties love them some Kelce, and Kelce loves finding the end zone. 

While Kelce has scored just eight touchdowns the last two regular seasons, he did score 12 in 2022, so he's not too far removed from a double-digit campaign. Retirement rumors also have been swirling around the star tight end, so perhaps he tries to go out with a bang with another memorable regular season.

Additionally, while Patrick Mahomes will have more rapport with second-year receiver Xavier Worthy and Hollywood Brown, Rashee Rice is suspended for the first six games of the year, meaning Mahomes could be looking to his longtime security blanket in Kelce early and often, especially in the red zone.

Patrick Mahomes Under 247.5 passing yards (-115, BetMGM)

Patrick Mahomes is still considered to be one of the best quarterbacks not just in the league, but all time, but he hasn't put up big numbers in recent years. The superstar actually finished with fewer than 4,000 yards for the first time in his career since taking over as Kansas City's full-time starter in 2018. 

Yes, Mahomes and Co. could come out cooking in this one after an embarrassing Super Bowl performance, but with his line at 247.5, I'm leaning Under here. He averaged 245.5 yards per game last year, the Chargers had the seventh-best pass defense in 2024 at 206.9 yards per game and Mahomes didn't clear this line in either of his two starts against Los Angeles last year. 

The Chiefs have become more of a ground-and-pound team that really leans on its strong defense over the last two years, and the results certainly speak for themselves. That's also the type of game the Chargers want to play, meaning possessions could be at a premium here as both teams aim to control the clock and the pace of play. Mahomes used to put up video game numbers, but his totals have dipped of late, which may frustrate bettors and Fantasy managers, but has been more than manageable for the Chiefs. Until we see Mahomes pick apart a very strong Chargers defense, the Under should be the play here at this current line.