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The first international game of the 2025 NFL season is on tap with a high-stakes AFC West showdown featuring the Kansas City Chiefs and the Los Angeles Chargers in the NFL Sao Paulo Game on Friday at 8 p.m. ET at Corinthians Arena. Kansas City is a 3-point favorite, while the over/under is 47.5. There will be millions of dollars on the line in NFL DFS tournaments, cash games and 50-50's on FanDuel and DraftKings, so finding DFS sleepers and building lineup variance will be critical for this single-game slate. Chiefs quarterback Patrick Mahomes has a lengthy track record of success against the Chargers, but should you include him in your NFL DFS lineups for the NFL Sao Paulo Game?

Other big names in the Chiefs vs. Chargers DFS player pool include Travis Kelce, Justin Herbert, Isiah Pacheco, Ladd McConkey and Najee Harris (eye), who has been cleared, but won't start as rookie Omarion Hampton gets the call. Who should you target when building NFL DFS lineups for Chargers vs. Chiefs? Before locking in any NFL DFS picks on sites like DraftKings and FanDuel for Chiefs vs. Chargers in the 2025 NFL Sao Paulo Game, be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure. 

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up.

Now, McClure has turned his attention to Chiefs vs. Cowboys in the 2025 Sao Paulo Game and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine, also new players can get $50 in Pick6 credits at DraftKings when they play $5: 

Top NFL DFS picks for Chiefs vs. Chargers

One of McClure's top NFL DFS picks for Friday is Chiefs tight end Travis Kelce. The future Hall of Fame selection is the NFL's active career leader in receptions (1,004), and he ranks third all-time in career receiving yards by a tight end (12,151). His 77 career touchdown receptions are a franchise record and the fifth-most by a tight end in NFL history.

Kelce is coming off one of the least productive seasons of his career, but still managed to catch 97 passes for 823 yards and three touchdowns. Kansas City has quietly put together a very solid group of wide receivers, which should take some of the pressure off Kelce -- especially in the red zone. Kelce remains a high-volume option with relatively low risk in DFS contests. See who else to roster here.

Part of McClure's optimal NFL DFS strategy also includes rostering Chiefs wide receiver Xavier Worthy. With Rashee Rice suspended for the first six games of the season, Worthy is poised to step into the WR1 role for Kansas City. The speedy Texas product made an impact as a rookie, hauling in 59 catches for 638 yards and six touchdowns, while also contributing on the ground with 20 carries for 104 yards and three more scores.

In Kansas City's final three regular-season games of 2024, Worthy was heavily involved in the team's offensive plans, drawing 31 targets and converting them into 21 catches for 190 yards and three touchdowns. He stayed hot in the playoffs, adding 19 receptions for 287 yards and three more scores across three postseason contests. He showed what he is truly capable of in the Chiefs' Super Bowl loss, catching eight passes for 157 yards and two scores. See who else to roster here, and new users can see the latest FanDuel promo code to get $300 in bonus bets at FanDuel if your $5 bet wins:

How to set NFL DFS lineups for Chargers vs. Chiefs

McClure is targeting another undervalued player who could explode for huge numbers in the 2025 Sao Paulo Game. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure's NFL DFS picks, at SportsLine.

So who is Mike McClure including in his optimal NFL DFS lineups for Chiefs vs. Chargers, and which under-the-radar player offers huge value? Visit SportsLine now to see optimal NFL DFS picks, NFL DFS rankings, NFL DFS advice and NFL DFS stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.